Engineering of CAR-less lentiviral vectors via ER retention-mediated CAR blockade
Liya Ma, Jian Wang, Mengwen Huang, Mengjiao Yao, Shuiling Yi, Kaiwen Zhang, Xingyi Ma, Hongxing Jason-Sun
The paper develops CLEAN-V, a lentiviral vector system that blocks CAR protein incorporation into viral particles, enabling safer in vivo CAR-T therapy without compromising functionality.
bioRxiv · Jun 23, 2026 · PreprintBioengineering