Spatial proteomics with 100+ markers with Highly Multiplexed MALDI-IHC
Mengze Zhang, John A Abbey, Pierre Bost, Genki Usui, Simon Haefliger, Simone E. Muenst, Mark J. Lim, Gargey B. Yagnik, Natalie de Souza, Kenneth J. Rothschild, Bernd Bodenmiller
This paper introduces a method for high-plex protein imaging using MALDI-IHC with PCMT-labeled antibodies and presents an open-source analysis pipeline called gutenTAG.
bioRxiv · Apr 18, 2025 · PreprintSystems Biology