The Vesicular Glutamate Transporter Modulates Sex and Region-Specific Differences in Dopaminergic Neuron α-Synuclein Toxicity by Modifying Cytosolic Dopamine Levels
Kevin Garzillo, Mia Perulli, Daniel T. Babcock
This study shows that lower vesicular glutamate transporter levels in dopamine neurons increase cytosolic dopamine, leading to mitochondrial dysfunction and increased α-synuclein A53T toxicity in female flies.
bioRxiv · Jan 21, 2026 · PreprintNeuroscience