Localized modulation of DNA supercoiling, triggered by the Shigella anti-silencer VirB, is sufficient to relieve H-NS-mediated silencing
Michael A. Picker, Monika M. A. Karney, Taylor M. Gerson, Alexander D. Karabachev, Juan Carlos Duhart, Joy A. McKenna, Helen J. Wing
The paper shows VirB modulates DNA supercoiling to relieve H-NS-mediated silencing in Shigella, independent of transcription or H-NS presence.
Nucleic Acids Research · Jan 31, 2023Peer-reviewedMolecular Biology