Synapse-based bispecific immune cell engager model predicts invariance in synapse behavior across different effector-to-tumor cell ratios
Michael W. Chevalier, Zhiwei Zhang, John Tolsma, Michael G. Zager
The paper develops a synapse-based ODE model for immune cell engagers that shows trimer per synapse invariance across effector-to-tumor ratios, improving mechanistic understanding of bispecific antibody function.
bioRxiv · Jun 29, 2026 · PreprintPharmacology & Toxicology