Patient-derived xenograft studies of fumarate hydratase (FH) -deficient uterine leiomyoma subtype.
Takuya Kajimura, Vanida Ann Serna, Emma G Amurgis, Michael L. Blumenfeld, Takeshi Kurita
This study investigates the growth of FH-deficient uterine leiomyoma using patient-derived xenografts, finding that E2 and P4 drive growth via SMTC proliferation and hypertrophy, with E2 sensitizing to P4.
bioRxiv · Jul 27, 2022 · PreprintGenetics