Takeshi Kurita

This study investigates the growth of FH-deficient uterine leiomyoma using patient-derived xenografts, finding that E2 and P4 drive growth via SMTC proliferation and hypertrophy, with E2 sensitizing to P4.

This paper identifies SIX1 as a critical transcription factor downstream of mesenchymal signals that cooperates with RUNX1 and SMAD4 to regulate {Delta}Np63 expression in Mullerian duct epithelium, leading to vaginal stratified squamous epithelium formation and preventing adenosis.