Author

Michael Lawrence

Genentech

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioinformatics· 3

Signature Assays, Organisms & Methods

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Organism:human· 2 Approach:statistical model· 2 Research Focus:variant calling· 2 Approach:experimental assay· 1 Research Focus:software / tool· 1 Assay:whole-exome sequencing· 1 Assay:whole-genome sequencing· 1

Frequent Co-Authors

Art Owen· 1 shared Bernd Fischer· 1 shared Dianne CookiD· 1 shared Eric Stawiski· 1 shared Jason Young· 1 shared Jeremiah Degenhardt· 1 shared Joseph Guillory· 1 shared Julian S. Gehring· 1 shared

Activity by Year

2015-2019 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 22 mutual co-author links

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1 shared paperBioinformatics

Art Owen

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3 papers

Recent·Most cited

plyranges: A grammar of genomic data transformation

Stuart A. Lee, Dianne Cook, Michael Lawrence

The paper introduces plyranges, an R/Bioconductor package that simplifies genomic data analysis by providing a grammar of genomic data transformation based on the GRanges data structure.

Genome biology · Jan 4, 2019Peer-reviewedBioinformatics

Genomic variant calling: Flexible tools and a diagnostic data set

Michael Lawrence, Melanie A. Huntley, Eric Stawiski, Art Owen, Thomas D Wu, Leonard D Goldstein, Yi Cao, Jeremiah Degenhardt, Jason Young, Joseph Guillory, Sherry Heldens, Marlena Jackson, Somasekar Seshagiri, Robert Gentleman

The paper develops software tools and a diagnostic dataset to evaluate variant calling pipelines, finding an FDR of 0.028 and FNR of 0.019 in a mixed cell line dataset.

bioRxiv · Sep 18, 2015 · PreprintBioinformatics

SomaticSignatures: Inferring Mutational Signatures from Single Nucleotide Variants

Julian S. Gehring, Bernd Fischer, Michael Lawrence, Wolfgang Huber

SomaticSignatures identifies mutational signatures from SNVs in cancer sequencing data, enabling cross-dataset analysis and integration with Bioconductor workflows.

bioRxiv · Mar 16, 2015Bioinformatics