Somasekar Seshagiri

The paper uses Sleeping Beauty mutagenesis to identify BACH2 and other genes that enhance CD8+ T cell persistence and function under chronic antigen stimulation, improving engineered T cell therapies.

This study shows that an FZD4/LRP5 agonist improves pericyte coverage and vascular integrity by enhancing PDGFB signaling in a mouse model of pericyte deficiency.

This study shows that C1QA maintains blood-retina barrier function and limits cystoid edema by supporting beta-catenin-dependent signaling in a mouse model of retinal disease.

This study shows that platelet PI3Kβ promotes breast cancer metastasis by enhancing tumor cell invasion and signaling pathways, suggesting it as a therapeutic target.

The paper presents high-quality near-chromosomal genome assemblies of Indian tigers and identifies genetic features related to their apex-predator traits and conservation.

This study identifies ACE2 receptor polymorphisms that may influence susceptibility to SARS-CoV-2 by altering the interaction between ACE2 and the viral S-protein.

This paper presents a de novo genome assembly of the olive baboon using long-read and Hi-C data, significantly improving contig size and chromosome scaffolding compared to the previous reference genome.

The paper characterizes the genetic structure of South Asian populations, identifies founder effects and high homozygosity, and develops a custom SNP array for genetic studies in the region.

The paper assesses the quality of the 1000 Genomes Project data by comparing phased haplotypes with experimental data and finds that rare variant phasing and imputation are unreliable due to limited sample size.

SCINA is a semi-supervised model for analyzing scRNA-Seq and flow cytometry data, improving accuracy and efficiency over unsupervised methods by leveraging gene signatures.

The paper develops software tools and a diagnostic dataset to evaluate variant calling pipelines, finding an FDR of 0.028 and FNR of 0.019 in a mixed cell line dataset.