A genome-wide almanac of co-essential modules assigns function to uncharacterized genes
Michael Wainberg, Roarke A. Kamber, Akshay Balsubramani, Robin M. Meyers, Nasa Sinnott-Armstrong, Daniel Hornburg, Lihua Jiang, Joanne Chan, Ruiqi Jian, Mingxin Gu, Anna Shcherbina, Michael M. Dubreuil, Kaitlyn K. Spees, Wouter R. A. Meuleman, Michael P. Snyder, , Anshul Bharat Kundaje
This paper develops a statistical method to identify gene co-essentiality, creating a genome-wide functional module almanac that predicts functions for 102 uncharacterized genes and validates key findings.
Nature Genetics · Apr 15, 2021Peer-reviewedGenomics