Joanne Chan

Polyclonal origins of human premalignant colorectal lesions

This study shows that many premalignant colorectal polyps contain multiple genetic lineages, indicating polyclonal origins rather than single-cell expansion.

Regulation of protein abundance in normal human tissues

The paper quantifies protein abundance across human tissues and identifies genetic factors influencing protein levels, revealing both shared and tissue-specific genetic architectures.

Improving design and normalization of multiplex proteomics study

The paper improves experimental design and normalization for multiplex proteomics by introducing reference samples and technical replicates, and presents ProMix to enhance analysis performance.

A genome-wide almanac of co-essential modules assigns function to uncharacterized genes

This paper develops a statistical method to identify gene co-essentiality, creating a genome-wide functional module almanac that predicts functions for 102 uncharacterized genes and validates key findings.

RobNorm: model-based robust normalization methodfor labeled quantitative mass spectrometry proteomics data

RobNorm is a normalization method for proteomics data that reduces systematic bias while preserving biological heterogeneity in heterogeneous samples.

A Quantitative Proteome Map of the Human Body

The paper quantifies protein levels across 32 human tissues and compares them to transcriptome data, revealing insights into post-transcriptional regulation and disease mechanisms.