Roarke A. Kamber

This study identifies regulators of FPR1 surface expression and internalization using CRISPR screens, revealing multiple pathways and previously unknown factors involved in receptor trafficking.

The paper develops HT-recruit to measure transcriptional effector function across contexts and identifies context-dependent effectors for CRISPR-based transcription control.

This study uses in vivo perturb-seq to analyze gene function and radiotherapy responses in glioblastoma by targeting cancer and microenvironment cells.

The paper identifies sortilin as the receptor mediating galectin-1 lysosomal trafficking through a CRISPR screen and demonstrates its use for siRNA delivery.

The paper shows that the yeast exportomer complex inhibits Atg36 phosphorylation to prevent pexophagy, revealing a mechanism linking organelle biogenesis to autophagy regulation.

This paper develops a statistical method to identify gene co-essentiality, creating a genome-wide functional module almanac that predicts functions for 102 uncharacterized genes and validates key findings.