Auto-methylation of the histone methyltransferase SetDB1 at its histone-mimic motifs ensures the spreading and maintenance of heterochromatin
Qing Tang, An Zhang, Michael Sullivan, Katalin Fejes Tóth, Alexei A. Aravin
The paper shows that SetDB1 auto-methylation at histone-mimic motifs enables heterochromatin spreading and maintenance through interactions with HP1 proteins.
bioRxiv · Jan 21, 2025 · PreprintGenetics