UBC9 and EME1 sumoylation foster ribosomal DNA damage repair in CPT response
Easa Nagamalleswari, Bakshi Karishma, Jan Breucker, Michaela Gschweitl, Román González‐Prieto, Nathalie Eisenhardt, Chronis Fatouros, Viduth K. Chaugule, Alfred C.O. Vertegaal, Andrea Pichler
The paper shows that UBC9 sumoylation enhances cell survival during CPT treatment by promoting EME1 sumoylation, which aids in ribosomal DNA repair.
bioRxiv · Apr 11, 2022 · PreprintMolecular Biology