Direct and indirect selection in a proofreading polymerase
Kabir B. Husain, Vedant Sachdeva, Riccardo Ravasio, Michele Peruzzo, Wanqiang Liu, Benjamin H. Good, Arvind Murugan
This study examines the evolution of mutation rates in proofreading polymerases by controlling direct and indirect selection, revealing dynamic evolutionary features and trade-offs between mutation rates and short-term fitness.
bioRxiv · Oct 14, 2024 · PreprintEvolutionary Biology