Donor whole blood DNA methylation is not a strong predictor of acute graft versus host disease in unrelated donor allogeneic haematopoietic cell transplantation
Amy P. Webster, Simone Ecker, Ismail Moghul, Xiaohong Liu, Pawan Dhami, Sarah J. Marzi, Dirk S. Paul, Michelle Kuxhausen, Stephanie Joi Lee, Stephen R. Spellman, Tao Wang, Andrew Feber, Vardhman K. Rakyan, Karl S. Peggs, Stephan Beck
This study investigates whether donor DNA methylation can predict acute graft-versus-host disease (aGVHD) in HCT, finding that a classifier developed from methylation data failed to validate in an independent cohort.
Frontiers in Genetics · Apr 3, 2024Peer-reviewedGenetic & Genomic Medicine