Pawan Dhami

Kandinsky identifies and analyzes cell neighbourhoods in spatial omics data to reveal functional interactions across biological contexts.

This study uses scRNA-seq to characterize periodontal granulation tissue, identifying novel cell populations and pathways involved in disease pathogenesis and regenerative potential.

This study identifies a molecular switch driven by neuronal activity and PGC-1 that promotes the maturation of parvalbumin interneurons during postnatal development.

The paper identifies shared CD8+ T-cell clones between skin and joint in psoriatic arthritis, suggesting clonal migration and coordinated inflammation.

This study identifies epigenetic changes and accelerated ageing in multifocal small intestinal neuroendocrine tumours, revealing altered metabolic gene regulation and tumour-specific methylation patterns.

This study investigates whether donor DNA methylation can predict acute graft-versus-host disease (aGVHD) in HCT, finding that a classifier developed from methylation data failed to validate in an independent cohort.

This study integrates single-cell RNA sequencing and spatial transcriptomics to map the temporal-spatial gene expression patterns during human pancreas development, identifying lineage dynamics and novel genes involved in beta cell maturation.

The paper benchmarks five DNA methylation platforms and shows imputation improves interoperability between them.

This paper introduces CAMDAC, a method to deconvolve tumor-normal DNA methylation profiles while accounting for copy number changes, revealing epigenetic instability and distinct patterns in lung cancer.

The paper identifies 61 novel mutations in the aged human testes, most affecting the RAS-MAPK pathway, showing evidence of selfish selection in the male germline.