Membrane surface geometry is a determinant of mitochondrial electron transfer and cellular adaptation
Miguel Gonzalez-Hernandez, Carmen Choya-Foces, Daymi Cespedes de los Rios, Enrique Calvo, José Luis Cabrera-Alarcón, Cristián Huck-Iriart, Rebeca Acín‐Pérez, Judith Langer, John W. Elrod, Jesús Vázquez, Jesús Ruı́z-Cabello, Susana Carregal‐Romero, Pablo Hernansanz‐Agustín
The paper shows that modifying ionic interactions with phospholipids prevents hypoxic adaptation by preserving inner mitochondrial membrane fluidity and CoQ transfer.
bioRxiv · Sep 18, 2026 · PreprintBiochemistry