PERK Activation by SB202190 Attenuates Amyloidogenesis via TFEB-induced Autophagy-Lysosomal Pathway
Mihyang Do, Jeongmin Park, Yubing Chen, So‐Young Rah, Thu-Hang Thi Nghiem, Jeong Heon Gong, Seong‐A Ju, Byung-Sam Kim, Rina Yu, Jeong Woo Park, Stefan W. Ryter, Young‐Joon Surh, Uh‐Hyun Kim, Yeonsoo Joe, Hun‐Taeg Chung
This study shows that SB202190 activates PERK, which enhances TFEB activity and the autophagy-lysosomal pathway, reducing amyloidogenesis in neurodegenerative diseases.
Aging · Feb 15, 2022Peer-reviewedNeuroscience