Spatial Single-Cell Atlas Reveals KSHV-Driven Broad Cellular Reprogramming, Progenitor Expansion, Immune and Vascular Remodeling in Kaposi's Sarcoma
Wen Meng, Arun Das, Harsh Sinha, Rana Naous, Paige M. Bracci, Mike McGrath, Yufei Huang, Shou‐Jiang Gao
This paper presents a spatial single-cell atlas of Kaposi's sarcoma, identifying CD34+ progenitor lymphatic endothelial cells as primary targets of KSHV and revealing mechanisms of tumor progression and immune modulation.
bioRxiv · Sep 1, 2025 · PreprintCancer Biology