This study uses spatial transcriptomics to compare how Asian and African Zika strains affect microglial states and brain tissue organization in mice, revealing strain-specific mechanisms of neuropathogenesis.

bioRxiv · May 5, 2026 · PreprintCell Biology

spatiAlytica: Viewer-Grounded Multimodal Agentic System for Interactive Spatial Omics Analysis

Arun Das, Kexun Zhang, Jifeng Song, Meiru Han, Angela Chen, Wen Meng, Hugh Galloway, Po-Yuan Chen, Sumin Jo, Zhentao Liu, Md Musaddaqul Hasib, Adam Officer, Harsh Sinha, Yu‐Chiao Chiu, Shou‐Jiang Gao, , Yufei Huang

spatiAlytica enables non-programmer biologists to perform interactive spatial omics analysis using natural language and a viewer-centric agentic system.

bioRxiv · May 4, 2026 · PreprintBioinformatics

Spatial Single-Cell Atlas Reveals KSHV-Driven Broad Cellular Reprogramming, Progenitor Expansion, Immune and Vascular Remodeling in Kaposi's Sarcoma

Wen Meng, Arun Das, Harsh Sinha, Rana Naous, Paige M. Bracci, Mike McGrath, Yufei Huang, Shou‐Jiang Gao

This paper presents a spatial single-cell atlas of Kaposi's sarcoma, identifying CD34+ progenitor lymphatic endothelial cells as primary targets of KSHV and revealing mechanisms of tumor progression and immune modulation.

bioRxiv · Sep 1, 2025 · PreprintCancer Biology