IL-9 signaling redirects CAR T cell fate toward CD8+ memory and CD4+ cycling states, enhancing anti-tumor efficacy
Sofía Castelli, Wesley V. Wilson, Uğur Uslu, Amanda Finck, Philipp C. Rommel, Charles‐Antoine Assenmacher, Sebastian J Atoche, Mikko Siurala, Maria Angela Aznar, Regina M. Young, Carl H. June
This study shows that adding IL-9 signaling to CAR T cells improves their anti-tumor effectiveness by shifting their fate toward memory and cycling states.
Immunity · Nov 21, 2025Peer-reviewedImmunology