Author

Regina M. Young

University of PennsylvaniaORCID 0000-0002-0158-9449Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

Click to filter author papers

Signature Assays, Organisms & Methods

Click to filter · or open tag

Organism:human· 3 Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Approach:statistical model· 2 Research Focus:cell type annotation· 1 Assay:CITE-seq· 1 Approach:deep learning· 1 Research Focus:differential expression· 1

Frequent Co-Authors

Carl H. JuneiD· 3 shared Aditi ChandraiD· 1 shared Alexander J. DimitriiD· 1 shared Alexander T. DilsiD· 1 shared Amanda FinckiD· 1 shared Amy E. BaxteriD· 1 shared Biliang HuiD· 1 shared Brian KeithiD· 1 shared

Activity by Year

2017-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

3 shared papersSynthetic Biology

Carl H. JuneORCID

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

A generalizable system for antigenic peptide targeting across HLA-I allotypes

Wyatt Blackson, Ean L. Small, Shirley M. Sun, Omkar Shinde, Ram Pantula, Sean J. Wang, Photis Rotsides, Haotian Du, Yi Sun, Daniel Hwang, Chloe S. Wang, Tianyu Lu, Eli Laskawy, Richa Kapoor, Muzamil Yaqub Want, , Nikolaos G. Sgourakis

The paper develops a system to create binders compatible across HLA allotypes, validated against clinically relevant antigens and demonstrated in CAR T cells.

bioRxiv · May 22, 2026 · PreprintSynthetic Biology

IL-9 signaling redirects CAR T cell fate toward CD8+ memory and CD4+ cycling states, enhancing anti-tumor efficacy

Sofía Castelli, Wesley V. Wilson, Uğur Uslu, Amanda Finck, Philipp C. Rommel, Charles‐Antoine Assenmacher, Sebastian J Atoche, Mikko Siurala, Maria Angela Aznar, Regina M. Young, Carl H. June

This study shows that adding IL-9 signaling to CAR T cells improves their anti-tumor effectiveness by shifting their fate toward memory and cycling states.

Immunity · Nov 21, 2025Peer-reviewedImmunology

TET2 regulates early and late transitions in exhausted CD8+ T-cell differentiation and limits CAR T-cell function

Alexander J. Dimitri, Amy E. Baxter, Gregory M. Chen, Caitlin R. Hopkins, Geoffrey T. Rouin, Hua Huang, Weimin Kong, Christopher Holliday, Volker Wiebking, Robert L. Bartoszek, Sydney Drury, Katherine Dalton, O. M. Koucky, Zeyu Chen, Josephine Ruth Giles, , Joseph A. Fraietta

This study shows that targeting TET2 in CAR T-cells improves their anti-tumor responses by limiting terminal exhaustion and enhancing therapeutic potential.

Science Advances · Nov 13, 2024Peer-reviewedImmunology

CAR T Cells Secreting IL18 Augment Antitumor Immunity and Increase T Cell Proliferation and Costimulation

Biliang Hu, Jiangtao Ren, Yanping Luo, Brian Keith, Regina M. Young, John Scholler, Yangbing Zhao, Carl H. June

This study shows that IL18-expressing CAR T cells enhance antitumor immunity, T cell proliferation, and costimulation, while reducing GVHD risk through a novel strategy.

Cell Reports · Sep 1, 2017Peer-reviewedSynthetic Biology