Space-time logic of liver gene expression at sublobular scale
Colas Droin, Jakob El Kholtei, Keren Bahar Halpern, Clémence Hurni, Milena Rozenberg, Sapir Muvkadi, Shalev Itzkovitz, Félix Naef
This study uses single-cell RNA-seq to show that many liver genes are both zonated and rhythmic, with multiplicative space-time effects, revealing spatio-temporal compartmentalization of liver function.
Nature Metabolism · Jan 11, 2021Peer-reviewedSystems Biology