Keren Bahar Halpern

Spatial transcriptomics of live healthy donor livers shows most hepatocyte genes are zonated, with key functions pericentrally shifted versus mouse, pig, boar and cow.

The paper uses spatial transcriptomics to analyze thyroid heterogeneity, identifying a damage-response thyrocyte state that balances with hormone-producing states across scales.

This study uses spatial and single-cell transcriptomics to show that celiac disease alters enterocyte states by promoting aberrant zonal co-expression and metaplastic cells.

This study creates a spatiotemporally resolved single-cell atlas of Plasmodium liver stage infection, revealing zone-specific parasite gene expression and immune responses in hepatocytes.

The paper identifies a subset of fetal enteroendocrine cells expressing insulin and beta cell genes, suggesting an extra-pancreatic source of beta cells.

This study uses single-cell RNA-seq to show that many liver genes are both zonated and rhythmic, with multiplicative space-time effects, revealing spatio-temporal compartmentalization of liver function.

The paper uses spatial sorting to characterize liver zonation by analyzing transcriptomics, microRNA arrays, and proteomics data.

The paper reconstructs the spatial expression of enterocytes along the intestinal villus axis and identifies zonation patterns in gene expression.