Andreas E. Moor

The paper presents the Human Gut Cell Atlas v1.0, a unified reference of gut cell diversity, revealing how tissue structure influences cellular composition and enabling disease and organoid analysis.

This study shows compressive stress activates a calcium-dependent pathway that reduces translation and proteostasis through multiple mechanisms, correlating with poor survival in pancreatic cancer.

This study identifies APOA1 as a marker of a late fetal colonic epithelial state that reappears after injury, linking it to colonic maturation and injury responses through interactions with WNT5A and regulation by HOXB7.

SubCellSpace identifies and characterizes subcellular mRNA localization patterns in spatial transcriptomics data using a computational framework.

RoCK and ROI improves single-cell transcriptomics by targeting specific transcripts and regions, enhancing detection of critical biological features.

The paper identifies CD4 memory T cell networks that form therapy-responsive immune niches in colorectal cancer liver metastases, determining chemotherapy response.

DemoTape is a computational method for demultiplexing targeted single-cell DNA sequencing data, showing improved performance over existing methods for RNA sequencing data.

ISCHIA identifies spatial co-occurrence patterns in healthy and inflamed human tissues using spatial transcriptomics data.

This study identifies TBX3 as a functional component of the Wnt/β-catenin complex in human colorectal cancer, showing it modulates metastasis-related transcription through direct protein interactions.

Sphere-sequencing identifies zonated genes and ligand-receptor interactions in mouse metastatic liver microenvironments at single cell resolution.

The paper uses a massively parallel reporter assay to identify RNA localization signals in neurons, revealing focused and broadly encoded motifs that influence mRNA localization to neurites and soma.

The paper identifies RNA localization elements in mouse 3' UTRs that direct transcripts to neurites and shows their enrichment in A/G residues.

The paper identifies TBX3 as a tissue-specific component of the Wnt/β-catenin enhanceosome, showing its role in transcriptional regulation and metastasis in colorectal cancer.

The paper uses spatial sorting to characterize liver zonation by analyzing transcriptomics, microRNA arrays, and proteomics data.

The paper reconstructs the spatial expression of enterocytes along the intestinal villus axis and identifies zonation patterns in gene expression.