Proteome-wide QTL mapping enables gene-protein-phenotype metabolic network construction in a genetically diverse MASLD mouse model
Margaret Lea Robinson, Wenyu Liu, Giorgia Benegiamo, Miller T Williams, Gordon Ian Smith, Samuel Klein, Johan H. Auwerx, Joshua J. Coon
This study maps proteome-wide QTLs in a MASLD mouse model to construct gene-protein-phenotype metabolic networks, identifying Ubr1 as a central regulator of proteostasis and lipid metabolism.
bioRxiv · Jul 28, 2026 · PreprintSystems Biology