Gordon Ian Smith

This study maps proteome-wide QTLs in a MASLD mouse model to construct gene-protein-phenotype metabolic networks, identifying Ubr1 as a central regulator of proteostasis and lipid metabolism.

This study shows that Pcpe2 in adipose tissue contributes to inflammation and fibrosis in obesity and that its absence reduces these effects and enhances adipocyte differentiation.

The paper shows immune cells regulate circulating adipocyte extracellular vesicle levels by clearing EVs, with reduced clearance in obesity leading to increased circulating adipoEVs.

This paper introduces a method using isotope tracing and mass isotopomer distributions to identify novel metabolites in mass spectrometry data, achieving 62% identification of unknown peaks.

This study identifies MXRA8 as a promoter of adipose tissue whitening that drives obesity, showing its role in reducing UCP1 expression and protecting against obesity in mice.