Pexidartinib plus FLT3-directed CAR-Macrophage for the treatment of FLT3-ITD-mutated acute myeloid leukemia in preclinical model
Fan Chen, Min-Hong Lv, Chun‐Wei Li, Yiqiong Zhang, Ze-Xiao Wei, Zhi Yuan, Jian-Yong Cao, Xinming Yang, Jing-Bo Xu, Li Wang, Alex Bai-Liang He
This study shows that combining pexidartinib with FLT3-directed CAR-macrophages reduces leukemic burden and improves survival in FLT3-ITD+ AML xenograft models.
bioRxiv · Sep 27, 2024 · PreprintCancer Biology