N-Ethylmaleimide-Sensitive Factor Deletion in Dopamine D2 Receptor Cells and Associated Neuronal and Behavioural Changes in Mice
Min-Jue Xie, Koshi Murata, Hiroshi Kuniishi, Yugo Fukazawa, Noriyoshi Usui, Hideo Matsuzaki
This study shows that deleting NSF in D2R-expressing cells in mice leads to neuronal loss, dopamine deficits, and ADHD-like behaviors, which can be mitigated by combining methylphenidate and a D2R agonist.
bioRxiv · Dec 19, 2025 · PreprintNeuroscience