Noriyoshi Usui

This study identifies region-specific transcriptomic changes in the prefrontal cortex and striatum of mice with early postnatal dopaminergic disturbance using bulk RNA-seq and WGCNA.

This study shows that deleting NSF in D2R-expressing cells in mice leads to neuronal loss, dopamine deficits, and ADHD-like behaviors, which can be mitigated by combining methylphenidate and a D2R agonist.

This study shows that Zbtb16 deletion in mice causes ASD and SCZ-like behaviors and neocortical developmental defects, with associated transcriptomic changes.

The paper investigates DNA methylation evolution in human brain cells, showing reduced CG methylation and increased CH methylation, linked to schizophrenia risk.

This study shows that impaired methylglyoxal detoxification in mice leads to mitochondrial dysfunction and schizophrenia-like behaviors.

The paper analyzes cell-type specific DNA methylation and transcriptomes in schizophrenia brains, finding reduced epigenetic distinction between cell types in schizophrenia.