A single-nucleus multiome analysis of transcriptome and chromatin accessibility reveals cell-type-specific immune modulation for chronic cannabis use among people with HIV infection
Mingrui Li, Kesava R. Asam, Xiaoke Duan, Grier P. Page, Yue Hu, Claudia Martinez, Mardge H. Cohen, Nancie M. Archin, Amir Valizadeh, Dana B. Hancock, Eric Otto Johnson, Bradley E. Aouizerat, Ke Xu
This study uses single-nucleus multi-omic analysis to show cannabis use in HIV patients alters gene expression and chromatin accessibility in immune cell types, with cell-type-specific effects on inflammation and transcription factor regulation.
bioRxiv · Feb 27, 2026 · PreprintGenomics