Author

Ke Xu

University of Notre Dame

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Same name, identified by ORCID

Biology Disciplines

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Genetic & Genomic Medicine· 2 Bioengineering· 1 Genetics· 1 Genomics· 1

Signature Assays, Organisms & Methods

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Organism:human· 4 Approach:statistical model· 4 Research Focus:GWAS / association mapping· 3 Assay:GWAS summary statistics· 2 Research Focus:benchmarking· 1 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1

Frequent Co-Authors

Bowei KangiD· 2 shared Lin CheniD· 2 shared Nathaniel MaydanchikiD· 2 shared Amei AmeiiD· 1 shared Amir ValizadehiD· 1 shared Amy C. JusticeiD· 1 shared Bradley E. AouizeratiD· 1 shared Brandon L. PierceiD· 1 shared

Activity by Year

2019-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 10 mutual co-author links

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2 shared papersGenetic & Genomic Medicine

Bowei KangORCID

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

A single-nucleus multiome analysis of transcriptome and chromatin accessibility reveals cell-type-specific immune modulation for chronic cannabis use among people with HIV infection

Mingrui Li, Kesava R. Asam, Xiaoke Duan, Grier P. Page, Yue Hu, Claudia Martinez, Mardge H. Cohen, Nancie M. Archin, Amir Valizadeh, Dana B. Hancock, Eric Otto Johnson, Bradley E. Aouizerat, Ke Xu

This study uses single-nucleus multi-omic analysis to show cannabis use in HIV patients alters gene expression and chromatin accessibility in immune cell types, with cell-type-specific effects on inflammation and transcription factor regulation.

bioRxiv · Feb 27, 2026 · PreprintGenomics

Identification of Novel Extracellular Vesicles Scaffold Proteins for Versatile Cargo Engineering

Tao Qiu, Rui Hu, Yuan Yi, Wenqiang Lu, Chuang Cui, Shuiqin Niu, Ke Xu

This study identifies raftlin (RFTN1) and poliovirus receptor (PVR) as novel scaffold proteins for engineering extracellular vesicles to load lumen and surface cargos, showing efficient in vivo delivery.

bioRxiv · Jan 5, 2026 · PreprintBioengineering

Integrative Mendelian Randomization for Detecting Exposure-by-group Interactions Using Group-Specific and Combined Summary Statistics

Ke Xu, Nathaniel Maydanchik, Bowei Kang, Jianhai Chen, Qixiang Chen, Gongyao Xu, Shinya Tasaki, David A. Bennett, Lin Chen

The paper introduces int2MR, a Mendelian randomization method for detecting exposure-by-group interactions using GWAS summary statistics, showing its effectiveness in identifying sex- and age-group-specific risk factors for ADHD and Alzheimer's disease.

PLoS Genetics · Sep 11, 2025Peer-reviewedGenetic & Genomic Medicine

An integrative multi-context Mendelian randomization method for identifying risk genes across human tissues

Yihao Lu, Ke Xu, Nathaniel Maydanchik, Bowei Kang, Brandon L. Pierce, Fan Yang, Lin Chen

The paper introduces mintMR, a multi-context MR framework that improves causal effect estimation by using consistent eQTLs across tissues and multi-view learning for disease-relevant tissue probabilities.

The American Journal of Human Genetics · Jul 24, 2024Peer-reviewedGenetic & Genomic Medicine

Retrospective Association Analysis of Longitudinal Binary Traits Identifies Important Loci and Pathways in Cocaine Use

Weimiao Wu, Zuoheng Wang, Ke Xu, Xinyu Zhang, Amei Amei, Joel E. Gelernter, Hongyu Zhao, Amy C. Justice

This study introduces L-BRAT and RGMMAT for analyzing longitudinal binary traits, identifies loci and pathways related to cocaine use, and replicates findings in an independent GWAS.

Genetics · Oct 7, 2019Peer-reviewedGenetics