Bradley E. Aouizerat

A single-nucleus multiome analysis of transcriptome and chromatin accessibility reveals cell-type-specific immune modulation for chronic cannabis use among people with HIV infection

This study uses single-nucleus multi-omic analysis to show cannabis use in HIV patients alters gene expression and chromatin accessibility in immune cell types, with cell-type-specific effects on inflammation and transcription factor regulation.

Age-Related Decline in NCKX4-Mediated Calcium Clearance Accelerates Aortic Remodeling and Drives Early Vascular Aging

This study identifies NCKX4 as a key regulator of vascular aging, showing its decline accelerates aortic remodeling and calcification in aged mice, particularly in females.

Longitudinal Associations Between MicroRNAs and Weight in the Diabetes Prevention Program

This study examines longitudinal associations between circulating microRNAs and weight changes over two years in the Diabetes Prevention Program.

A hierarchical Bayesian interaction model to estimate cell-type-specific methylation quantitative trait loci incorporating priors from cell-sorted bisulfite sequencing data

A New Monocyte Epigenetic Clock Reveals Effects of Alcohol Consumption on Epigenetic Aging in Three Independent Cohorts

This study develops a monocyte-based DNA methylation clock (MonoDNAmAge) and shows its nonlinear relationship with alcohol consumption across three cohorts.

A genomic variant of ALPK2 is associated with increased liver fibrosis risk in HIV/HCV coinfected women

The paper identifies a genomic variant in ALPK2 associated with increased liver fibrosis risk in HIV/HCV coinfected women using clinical data from the WIHS cohort.

scCorr: A graph-based k-partitioning approach for single-cell gene-gene correlation analysis

scCorr reduces zero values in single-cell RNA-seq by merging homology cells, improving gene-gene correlation detection for network analysis.

Single-cell Transcriptome Mapping Identifies Common and Cell-type Specific Genes Affected by Acute Delta9-tetrahydrocannabinol in Humans

This study identifies 294 genes affected by acute THC administration in human immune cells, including 69 common and 225 cell-type specific genes.