Characterization of a novel type III CRISPR-Cas effector provides new insights into the allosteric activation and suppression of the Cas10 DNase
Jinzhong Lin, Mingxia Feng, Heping Zhang, Qunxin She
This study characterizes a type III CRISPR-Cas system, revealing how RNA binding allosterically activates and suppresses Cas10 DNase activity through specific 3' anti-tag interactions.
Cell Discovery · May 11, 2020Peer-reviewedMolecular Biology