Cancer BiologybioRxiv
Tissue of origin detection for cancer tumor using low-depth cfDNA samples through combination of tumor-specific methylation atlas and genome-wide methylation density in graph convolutional neural networks
Trong Hieu Nguyen, Nhu Nhat Tan Doan, Trung Hieu Tran…·Minh Duy Phan
The paper develops a model combining tumor-specific methylation atlas and cfDNA features to improve tissue-of-origin detection in low-depth cfDNA samples.
DOI 10.1186/s12967-024-05416-z