Modeling the Interplay of Sex Hormones in Cardiac Hypertrophic Signaling
Adhithi Lakshmikanthan, Minnie Kay, Pim J. A. Oomen
The paper develops a logic-based systems biology model of cardiac hypertrophy incorporating sex hormones and validates it to show testosterone has a greater impact on hypertrophy than estradiol.
PLoS Computational Biology · Dec 10, 2025Peer-reviewedSystems Biology