Author

Adhithi Lakshmikanthan

University of California, IrvineORCID 0000-0003-4048-9675Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Bioengineering· 1 Systems Biology· 1

Signature Assays, Organisms & Methods

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Approach:statistical model· 2 Research Focus:benchmarking· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:gene regulatory network inference· 1 Organism:human· 1

Frequent Co-Authors

Pim J. A. OomeniD· 2 shared Felix PlappertiD· 1 shared Minnie Kay· 1 shared Weining SheniD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

4 top collaborators · 4 mutual co-author links

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2 shared papersBioengineering

Pim J. A. OomenORCID

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2 papers

Recent·Most cited

BioengineeringbioRxivPreprintSep 18, 2026

Representing Sex in Cardiovascular Models: Calibrating Reference Parameters from Healthy Cohorts

Adhithi Lakshmikanthan, Felix Plappert, Weining Shen, Pim J. A. Oomen

This study calibrates reduced-order cardiovascular models using healthy male and female cohorts to establish sex-specific parameter ranges for more inclusive cardiovascular simulations.

DOI 10.64898/2026.09.17.752488

humanstatistical model

𝕏 PostBluesky

Systems BiologyPLoS Computational BiologyPeer-reviewedDec 10, 2025

Modeling the Interplay of Sex Hormones in Cardiac Hypertrophic Signaling

Adhithi Lakshmikanthan, Minnie Kay, Pim J. A. Oomen

The paper develops a logic-based systems biology model of cardiac hypertrophy incorporating sex hormones and validates it to show testosterone has a greater impact on hypertrophy than estradiol.

2 citations

statistical modelcell type annotation

𝕏 PostBluesky