Pim J. A. Oomen

Representing Sex in Cardiovascular Models: Calibrating Reference Parameters from Healthy Cohorts

This study calibrates reduced-order cardiovascular models using healthy male and female cohorts to establish sex-specific parameter ranges for more inclusive cardiovascular simulations.

Multiscale Computational Modeling of the Cardiopulmonary Consequences of Postnatal Hyperoxia with Implications for Preterm Born Children

This paper develops a multiscale computational model to simulate cardiopulmonary effects of postnatal hyperoxia in rats, showing agreement with experimental data and capturing abnormalities seen in preterm humans.

Modeling the Interplay of Sex Hormones in Cardiac Hypertrophic Signaling

The paper develops a logic-based systems biology model of cardiac hypertrophy incorporating sex hormones and validates it to show testosterone has a greater impact on hypertrophy than estradiol.

A computational model to study hemodynamics during atrial fibrillation

This paper presents a computational model of hemodynamics during atrial fibrillation that fits clinical data from 17 patients, achieving high accuracy in blood pressure and ejection fraction measurements.

Synergistic Biophysics and Machine Learning Modeling to Rapidly Predict Cardiac Growth Probability

This study develops a computational framework combining biophysics and machine learning to predict cardiac growth probability, validated using canine MVR data.