Loss of MECP2 leads to induction of p53 and cell senescence
Minori Ohashi, Elena Korsakova, Denise E. Allen, Peiyee Lee, Kai Fu, Benni S. Vargas, Jessica K. Cinkornpumin, Carlos Salas, Jenny C. Park, Igal Germanguz, Justin Langerman, Constantinos Chronis, Edward Kuoy, Stephen S. Tran, Xinshu Grace Xiao, , William E. Lowry
This study shows that loss of MECP2 in neurons leads to p53 induction and cell senescence, causing dendritic defects.
Stem Cell Reports · May 1, 2018Peer-reviewedDevelopmental Biology