Human NHE1 binds full-length calcineurin with high affinity and inhibits substrate dephosphorylation
Aileen Sorg, Jan-Simon Haas, Mio Heinrich, Sophia Gauss, Bianca A. Kern, Viviane Timmermann, Evgeny V. Mymrikov, Carola Hunte
This study quantifies the interaction between full-length human calcineurin and NHE1-CnBD under different activation states and shows NHE1 inhibits substrate dephosphorylation.
bioRxiv · Sep 13, 2026 · PreprintBiochemistry