Author

Bianca A. Kern

University of FreiburgORCID 0009-0004-7908-6587Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Organism:mouse· 1 Research Focus:protein folding & dynamics· 1 Assay:protein structure· 1

Frequent Co-Authors

Carola HunteiD· 2 shared Evgeny V. MymrikoviD· 2 shared A.K. IaroslavtcevaiD· 1 shared Aileen Sorg· 1 shared Anna KöttgeniD· 1 shared C. SteckiD· 1 shared Christophe WirthiD· 1 shared Jan-Simon HaasiD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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2 shared papersBiochemistry

Carola HunteORCID

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2 papers

Recent·Most cited

Human NHE1 binds full-length calcineurin with high affinity and inhibits substrate dephosphorylation

Aileen Sorg, Jan-Simon Haas, Mio Heinrich, Sophia Gauss, Bianca A. Kern, Viviane Timmermann, Evgeny V. Mymrikov, Carola Hunte

This study quantifies the interaction between full-length human calcineurin and NHE1-CnBD under different activation states and shows NHE1 inhibits substrate dephosphorylation.

bioRxiv · Sep 13, 2026 · PreprintBiochemistry

Molecular determinants of selective and high-affinity binding of the scaffold protein PDZK1 to the transporter URAT1

Evgeny V. Mymrikov, Christophe Wirth, Jonas Immanuel Heinicke, Julian Goll, Bianca A. Kern, C. Steck, A.K. Iaroslavtceva, Tobias Mühlethaler, Anna Köttgen, Carola Hunte

This study identifies molecular determinants of high-affinity PDZK1 binding to URAT1 using biophysical and structural methods, revealing species-specific interactions.

Journal of Molecular Biology · Dec 25, 2025Peer-reviewedBiochemistry