Exploiting fluctuations in gene expression to detect causal interactions between genes
Euan Joly-Smith, Mir Mikdad Talpur, Paige Allard, Fotini Papazotos, Laurent Potvin-Trottier, Andreas Hilfinger
This paper introduces a method to detect causal gene interactions using natural expression fluctuations in genetically identical cells, validated in E. coli synthetic circuits.
eLife · Dec 16, 2025Peer-reviewedSystems Biology