BiochemistrybioRxiv
Robust Sequence Determinants of α-Synuclein Toxicity in Yeast Implicate Membrane Binding
Robert W. Newberry, Taylor Arhar, Jean Costello…·Jenna Pell
The paper uses deep mutational scanning in yeast to show that a toxic conformation of α-synuclein is stable under chemical perturbations, while mutations affecting toxicity are influenced by these perturbations.
DOI 10.1021/acschembio.0c00339