Combinatorial effects on gene expression at the Lbx1/Fgf8 locus resolve Split-Hand/Foot Malformation type 3
Giulia Cova, Juliane Glaser, Robert Schöpflin, Salaheddine Ali, Cesar A. Prada‐Medina, Martin Franke, Rita Falcone, Miriam Federer, Emanuela Ponzi, Romina Ficarella, Francesca Novara, Lars Wittler, Bernd Timmermann, Mattia Gentile, Orsetta Zuffardi, , Stefan Mundlos
The paper investigates how genomic rearrangements at the Lbx1/Fgf8 locus cause SHFM3 by altering chromatin structure and gene expression in mice.
bioRxiv · Feb 9, 2022 · PreprintGenetics