Giulia Cova

This study shows that DNA damage in glioblastoma cells leads to long-term chromatin changes and gene expression reprogramming, affecting cellular function and tumor outcomes.

The paper shows cohesin collisions maintain ordered nucleosome architecture at CTCF sites and promoters, independent of CTCF occupancy or cohesin levels.

The paper shows that activation of an LTR retrotransposon in the embryo leads to viral-like particle production, causing limb malformations through apoptotic cell death.

The paper creates a database of multi-target CRISPR-Cas9 guide-RNAs with on- and off-target scores and provides a web tool for selecting these guide-RNAs.

The paper investigates how CTCF mutations affect chromatin accessibility, cohesin binding, and gene regulation through multivariate modeling and mutant perturbations.

The paper investigates how CTCF, cohesin, and TFs influence nucleosome repositioning and chromatin insulation across cell states using mouse and human data.

The paper investigates how clustered-CTCF boundaries function in vivo, showing that individual CTCF sites can override other factors and that insulation strength modulates gene expression and phenotypes.

The paper investigates how genomic rearrangements at the Lbx1/Fgf8 locus cause SHFM3 by altering chromatin structure and gene expression in mice.