An improved polygenic score for Parkinson's disease partly explains variable penetrance of genetic Parkinson's disease
Sebastian Sendel, Zied Landoulsi, Katja Lohmann, Björn‐Hergen Laabs, Meike Kasten, Eva‐Juliane Vollstedt, Tatiana Usnich, Alexander Balck, Daniela Berg, Dheeraj Reddy Bobbili, Max Borsche, André Franke, Henrike Hanßen, Emadeldin Hassanin, Andrew A. Hicks, , Amke Caliebe
The paper develops an improved polygenic score for idiopathic Parkinson's disease, showing higher discriminative performance and explaining variable penetrance in genetic forms of the disease.
medRxiv · Feb 28, 2025 · PreprintGenetic & Genomic Medicine