Amke Caliebe

The paper adapts the Elston-Stewart algorithm to efficiently calculate exact Y-STR match probabilities in pedigrees, outperforming simulation-based methods for most cases.

The paper investigates whether YHRD's metapopulations are self-evident by analyzing genetic structure using cluster analysis and finds weak genetic structure that does not support clear subgrouping.

The paper develops a method to estimate the time-of-day bloodstains were deposited using targeted RNA sequencing of 74 diurnally rhythmic markers, achieving 78% accuracy within 4 hours.

The paper validates a mitochondrial polygenic score for Parkinson's disease across diverse populations, finding strong associations in Europeans and Ashkenazi Jews but not in other ancestries.

The paper develops an improved polygenic score for idiopathic Parkinson's disease, showing higher discriminative performance and explaining variable penetrance in genetic forms of the disease.

The paper traces the origin and spread of the IL23R variant rs11209026-A in Europe, linking its frequency changes to Neolithic agricultural practices and its protective role against inflammatory bowel diseases.

The paper examines how polygenic scores and lifestyle factors influence age at onset in Parkinson's disease, finding that lifestyle factors have a larger impact than genetic variants.

This paper introduces aps-lm, a linear regression method that predicts outcomes from incomplete datasets without imputation, showing improved accuracy and reduced bias compared to imputation strategies.

This study examines how a mitochondrial polygenic score interacts with environmental factors to influence age at onset in LRRK2-PD and iPD, finding ethnic-specific effects and gene-environment interactions.