Björn‐Hergen Laabs

Validation of a Mitochondrial Polygenic Score for Parkinson's Disease

The paper validates a mitochondrial polygenic score for Parkinson's disease across diverse populations, finding strong associations in Europeans and Ashkenazi Jews but not in other ancestries.

An improved polygenic score for Parkinson's disease partly explains variable penetrance of genetic Parkinson's disease

The paper develops an improved polygenic score for idiopathic Parkinson's disease, showing higher discriminative performance and explaining variable penetrance in genetic forms of the disease.

FGF14 repeat length and mosaic interruptions: modifiers of SCA27B?

The paper investigates FGF14 repeat interruptions in ataxia patients and unaffected individuals, finding that mosaic interruptions (mDRILS) correlate with age at onset and affect pathogenicity.

The combined effect of lifestyle factors and polygenic scores on age at onset in Parkinson's disease

The paper examines how polygenic scores and lifestyle factors influence age at onset in Parkinson's disease, finding that lifestyle factors have a larger impact than genetic variants.

Identification of representative trees in random forests based on a new tree-based distance measure

The paper introduces a new tree-based distance measure for random forests to identify representative trees, showing its effectiveness in capturing genetic interactions and replicating GWAS results.

Interaction of mitochondrial polygenic score and environmental factors in LRRK2 p.Gly2019Ser parkinsonism

This study examines how a mitochondrial polygenic score interacts with environmental factors to influence age at onset in LRRK2-PD and iPD, finding ethnic-specific effects and gene-environment interactions.