Brain mitovesicles undergo stage-specific remodelling during the progression of amyloid-β pathology
Liesbeth Voorbraeck, Jesus Alarcon-Gil, Mite Mijalkov, Massimiliano Passaretti, Zhibai Cao, Doste R Mamand, Sara Garcia-Ptacek, Julianna Kele, Stephanie L. Fowler, Maria Ankarcrona, Joana B. Pereira, Luana Naia
This study shows that mitovesicles from Alzheimer's disease mouse models undergo stage-specific proteomic changes that reflect mitochondrial dysfunction and provide a conserved disease signature in humans.
bioRxiv · Nov 3, 2026 · PreprintNeuroscience